Article
Chromosome 14 alteration is associated with increased collagenase expression and the metastatic potential of murine melanomas.
Cancer genetics and cytogenetics - 1 Nov 1996
Dave B J, Singh R, Fidler I J, Pathak S
Abstract excerpt
The purpose of this study was to correlate abnormalities in chromosome 14 with the invasive metastatic phenotype of K-1735 murine melanoma cells. Low metastatic K-1735 clone 10 and clone 23 cells were transfected with either basic fibroblast growth factor (bFGF), Kaposi's fibroblast growth factor (kFGF), or c-H-ras gene. A high number of bFGF- and H-ras-transfected cells exhibited chromosome 14 rearrangements....
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