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Article

Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide.

British journal of cancer - 1 Sept 2003

Kanzawa T, Germano I M, Kondo Y, Ito H, Kyo S, Kondo S

Abstract excerpt

Temozolomide (TMZ, 3,4-dihydro-3-methyl-4-oxoimidazo [5,1-d]-as-tetrazine-8-carboxamide) is a new alkylating agent with promising antitumour efficacy for malignant gliomas. The resistance of tumour cells to TMZ is primarily associated with levels of the alkylguanine alkyltransferase (AGT). O(6)-benzylguanine (O(6)-BG), an inhibitor for AGT, reduced resistance to TMZ. Recently, it has been demonstrated that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12942127
DOI: 10.1038/sj.bjc.6601193
PMCID: PMC2394478

Genes

AGT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide.PMID 12942127Read ↗

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