Article
Overexpression of a human and a fungal ABC transporter similarly suppresses the differentiation defects of a fungal peroxisomal mutant but introduces pleiotropic cellular effects.
Molecular microbiology - 1 Sept 2003
Boisnard Stéphanie, Zickler Denise, Picard Marguerite, Berteaux-Lecellier Véronique
Abstract excerpt
Among the peroxisome membrane proteins, some are required for peroxisome biogenesis (e.g. PEX2) while others are not, e.g. ABC (ATP-binding cassette) transporters. Unexpectedly, overproduction of the peroxisomal ABC transporter PMP70 was found to be able to restore peroxisome biogenesis in mammal...
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