Article
Restoration of PEX2 peroxisome assembly defects by overexpression of PMP70.
European journal of cell biology - 1 Aug 1998
Gärtner J, Brosius U, Obie C, Watkins P A, Valle D
Abstract excerpt
The mutant Chinese hamster ovary (CHO) cell line Z78/C has defective peroxisome assembly due to a missense mutation in PEX2, the gene which encodes the 35 kDa peroxisomal integral membrane protein. In humans, PEX2 mutations are responsible for complementation group 10 of the human peroxisome biog...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Blotting, Northern
- CHO Cells
- Cloning, Molecular
- Cricetinae
- DNA, Complementary
- Gene Expression Regulation, Enzymologic
- Humans
- Membrane Proteins
- Microbodies
- Mutagenesis
- Oxidation-Reduction
- Peroxisomal Biogenesis Factor 2
- Phenotype
- Protein Binding
- RNA, Messenger