Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

There is no increase in frequency of somatic mutations in metastases compared with primary colorectal carcinomas with microsatellite instability.

Genes, chromosomes & cancer - 1 Oct 2003

Barnetson Rebecca, Eckstein Robert, Robinson Bruce, Schnitzler Margaret

Abstract excerpt

This study investigates the molecular features of metastasis in sporadic colon carcinomas with high-level microsatellite instability (MSI-H). DNA from 51 regions from 10 MSI-H metastatic carcinomas and 26 corresponding metastases was analyzed for mutations in TGFBRII, IGFIIR, BAX, MSH3, MSH6, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endothelial Growth Factors
Share to Intercellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymph Nodes

Share to Lymphatic Metastasis

Share to Lymphokines

Share to Peritoneal Neoplasms

Share to Vascular Endothelial Growth Factor A

Share to Vascular Endothelial Growth Factors

Source

Identifiers

PMID: 12939742
DOI: 10.1002/gcc.10262

Genes

BAX
MSH3
MSH6
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12939742-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

There is no increase in frequency of somatic mutations in metastases compared with primary colorectal carcinomas with microsatellite instability.PMID 12939742Read ↗

Genetic alterations of sporadic colorectal cancer with microsatellite instability, especially characteristics of primary multiple colorectal cancers.Semantic proximity Read ↗

Reduced Likelihood of Metastases in Patients with Microsatellite-Unstable Colorectal CancerSemantic proximity Read ↗

Microsatellite instability in patients with multiple primary cancers of the gastrointestinal tract.Semantic proximity Read ↗

Consequences of a high incidence of microsatellite instability and BRAF‐mutated tumors: A population‐based cohort of metastatic colorectal cancer patientsSemantic proximity Read ↗

Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.Semantic proximity Read ↗

Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability.Semantic proximity Read ↗

Genetic and molecular diversity of colon cancer hepatic metastases.Semantic proximity Read ↗

Mutations in TGFbeta-RII and BAXmediate tumor progression in the later stages of colorectal cancer with microsatellite instabilitySemantic proximity Read ↗

Unique genetic profile of sporadic colorectal cancer liver metastasis versus primary tumors as defined by high-density single-nucleotide polymorphism arrays.Semantic proximity Read ↗

Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability.Semantic proximity Read ↗

Mutations associated with microsatellite unstable colorectal carcinomas exhibit widespread intratumoral heterogeneity.Semantic proximity Read ↗

High concordance rate of KRAS/BRAF mutations and MSI-H between primary colorectal cancer and corresponding metastases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.