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The <i>Helicobacter pylori</i>'s protein VacA has direct effects on the regulation of cell cycle and apoptosis in gastric epithelial cells

4 Sept 2007

Abstract excerpt

In this study, we have evaluated the effects on cell cycle regulation of VacA alone and in combination with other two Helicobacter pylori proteins, cytotoxin-associated protein (CagA) and HspB, using the human gastric epithelial cells (AGS). Our results indicate that VacA alone was able to inhibit the G1 to S progression of the cell cycle. The VacA capacity of inhibiting cell progression from G1 to S phase was...

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PMID: 17786942
DOI: 10.1002/jcp.21242

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