Article
Transforming growth factor beta1 overexpression in the nigrostriatal system increases the dopaminergic deficit of MPTP mice.
Molecular and cellular neurosciences - 1 Aug 2003
Sánchez-Capelo Amelia, Colin Philippe, Guibert Bernard, Biguet Nicole Faucon, Mallet Jacques
Abstract excerpt
Idiopathic Parkinson's disease (PD) is characterized by mesencephalic dopaminergic neuron cell death and striatal dopamine (DA) depletion. The factors involved in the pathogenesis of the disease are still unknown. Transforming growth factor beta1 (TGFbeta1) is increased in the striatum of patients with PD. However, the effect of this increase is not known. Here, we show that overexpression of TGFbeta1, by...
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