Article
Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis.
The pharmacogenomics journal - 1 Jan 2003
Ujike H, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Sora I, Iyo M, Katsu T, Nomura A, Nakata K, Ozaki N
Abstract excerpt
Susceptibility to drug dependence and drug-induced psychoses is influenced not only by the pharmacological effects of the drug but also by the genetic factors of the individual. To clarify the latter, we investigated the association between methamphetamine (METH) dependence/psychosis and the hDAT1 gene (SLC6A3) encoding the dopamine transporter, which is the primary site of METH activity in the brain. Four exonic...
Topics
- Adult
- Amphetamine-Related Disorders
- Dopamine Plasma Membrane Transport Proteins
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Male
- Membrane Glycoproteins
- Membrane Transport Proteins