Article
A positively charged side chain at position 154 on the beta8-alphaE loop of HIV-1 RT is required for stable ternary complex formation.
Nucleic acids research - 1 Sept 2003
Sharma Bechan, Kaushik Neerja, Upadhyay Alok, Tripathi Snehlata, Singh Kamalendra, Pandey Virendra N
Abstract excerpt
Lys154 is the only positively charged residue located in the VLPQGWK motif on the beta8-alphaE loop at the junction of the fingers and palm subdomains of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). Some of the conserved residues in this motif are critical for RT function, while others have been shown to confer nucleoside drug resistance and fidelity to the enzyme. In order to understand...
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