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Article

A positively charged side chain at position 154 on the beta8-alphaE loop of HIV-1 RT is required for stable ternary complex formation.

Nucleic acids research - 1 Sept 2003

Sharma Bechan, Kaushik Neerja, Upadhyay Alok, Tripathi Snehlata, Singh Kamalendra, Pandey Virendra N

Abstract excerpt

Lys154 is the only positively charged residue located in the VLPQGWK motif on the beta8-alphaE loop at the junction of the fingers and palm subdomains of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). Some of the conserved residues in this motif are critical for RT function...

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Share to Binding, Competitive
Share to DNA-Directed DNA Polymerase
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoretic Mobility Shift Assay

Share to HIV Reverse Transcriptase

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Identifiers

PMID: 12930968
DOI: 10.1093/nar/gkg708
PMCID: PMC212807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12930968-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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