Article
The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs.
FEBS letters - 25 Apr 2005
Auwerx Joeri, Van Nieuwenhove Joke, Rodríguez-Barrios Fátima, de Castro Sonia, Velázquez Sonsoles, Ceccherini-Silberstein Francesca, De Clercq Erik, Camarasa María-José, Perno Carlo-Federico, Gago Federico, Balzarini Jan
Abstract excerpt
Amino acids N137 and P140 in the p51 subunit of HIV-1 reverse transcriptase (RT) are part of the beta7-beta8-loop that contributes to the formation of the base of the non-nucleoside RT inhibitor (NNRTI)-binding pocket and makes up a substantial part of the dimerization interface. Amino acid P95 in p66 also markedly contributes to the dimerization binding energy. Nine RT mutants at amino acid 137 were constructed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.