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Article

Elongator function depends on antagonistic regulation by casein kinase Hrr25 and protein phosphatase Sit4.

Molecular microbiology - 1 Sept 2009

Mehlgarten Constance, Jablonowski Daniel, Breunig Karin D, Stark Michael J R, Schaffrath Raffael

Abstract excerpt

In yeast, the role for the Elongator complex in tRNA anticodon modification is affected by phosphorylation of Elongator subunit Elp1. Thus, hyperphosphorylation of Elp1 due to inactivation of protein phosphatase Sit4 correlates with Elongator-minus phenotypes including resistance towards zymocin, a tRNase cleaving anticodons of Elongator-dependent tRNAs. Here we show that zymocin resistance of casein kinase hrr25...

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Share to Histone Acetyltransferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19656297
DOI: 10.1111/j.1365-2958.2009.06811.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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