Article
Neuroectodermal differentiation from mouse multipotent adult progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2003
Jiang Yuehua, Henderson Dori, Blackstad Mark, Chen Angel, Miller Robert F, Verfaillie Catherine M
Abstract excerpt
We recently showed that a rare cell from murine bone marrow, which we termed multipotent adult progenitor cells (MAPCs), can be expanded for >120 population doublings. Mouse (m)MAPCs differentiate into mesenchymal lineage cells as well as endothelium and endoderm, and, when injected in the blastocyst, mMAPCs contribute to most if not all somatic cell lineages including the different cell types of the brain. Our...
Topics
- Animals
- Astrocytes
- Base Sequence
- Cell Differentiation
- Cells, Cultured
- Coculture Techniques
- Culture Media, Conditioned
- DNA, Complementary
- Dopamine
- Ectoderm
- Hematopoietic Stem Cells
- Mice
- Neurons