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Article

X inactivation-specific methylation of LINE-1 elements by DNMT3B: implications for the Lyon repeat hypothesis.

Human molecular genetics - 1 Oct 2003

Hansen R Scott

Abstract excerpt

Lyon has proposed that long interspersed nuclear element 1 (LINE-1 or L1) repeats may be mediators for the spread of X chromosome inactivation. Cells from ICF patients who are deficient in one of the DNA methyltransferases, DNMT3B, provide an opportunity to explore and refine this hypothesis. Sou...

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Share to Chromosomes, Human, X
Share to CpG Islands
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3B

Share to Dosage Compensation, Genetic

Share to Immunologic Deficiency Syndromes

Share to Long Interspersed Nucleotide Elements

Share to Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 12925568
DOI: 10.1093/hmg/ddg268

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12925568-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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