Article
Expansion of clonotype-restricted HLA-identical maternal CD4+ T cells in a patient with severe combined immunodeficiency and a homozygous mutation in the Artemis gene.
Clinical immunology (Orlando, Fla.) - 1 Aug 2003
Kobayashi Norimoto, Agematsu Kazunaga, Nagumo Haruo, Yasui Kozo, Katsuyama Yoshihiko, Yoshizawa Kaname, Ota Masao, Yachie Akihiro, Komiyama Atsushi
Abstract excerpt
We have observed a male infant with severe combined immunodeficiency (SCID) responsible for Artemis gene mutation, in whom marked expansion of the transplacentally grafted maternal CD4(+) T cells was observed in various tissues. His class I and II major histocompatibility antigens (MHC) were identical to his mother's. We analyzed the T-cell populations within target tissues at a molecular level in order to...
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