Article
Expansion of a maternally derived monoclonal T cell population with CD3+/CD8+/T cell receptor-gamma/delta+ phenotype in a child with severe combined immunodeficiency.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1991
Wahn V, Yokota S, Meyer K L, Janssen J W, Hansen-Hagge T E, Knobloch C, Koletzko S, Stein H, Friedrich W, Bartram C R
Abstract excerpt
The diagnosis of severe combined immunodeficiency complicated by chronic graft-vs-host disease affecting liver and skin in association with engraftment of maternal T cells was established in a 5-mo-old boy. Detailed immunologic and molecular genetic studies were performed because a unique T cell...
Topics
- Alleles
- Antigens, Differentiation, T-Lymphocyte
- Base Sequence
- Blotting, Southern
- CD3 Complex
- CD8 Antigens
- Clone Cells
- DNA Fingerprinting
- Flow Cytometry
- Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
- Molecular Sequence Data
- Oligonucleotides
- Polymerase Chain Reaction