Article
Expansion of a maternally derived monoclonal T cell population with CD3+/CD8+/T cell receptor-gamma/delta+ phenotype in a child with severe combined immunodeficiency.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1991
Wahn V, Yokota S, Meyer K L, Janssen J W, Hansen-Hagge T E, Knobloch C, Koletzko S, Stein H, Friedrich W, Bartram C R
Abstract excerpt
The diagnosis of severe combined immunodeficiency complicated by chronic graft-vs-host disease affecting liver and skin in association with engraftment of maternal T cells was established in a 5-mo-old boy. Detailed immunologic and molecular genetic studies were performed because a unique T cell phenotype was identified on initial evaluation. A major proportion of the patient's peripheral T cells expressed a CD8+...
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