Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific inhibition of transcription factor NF-kappaB through intracellular protein delivery of I kappaBalpha by the Herpes virus protein VP22.

Oncogene - 14 Aug 2003

Stroh Christopher, Held Jürgen, Samraj Ajoy Kumar, Schulze-Osthoff Klaus

Abstract excerpt

In many cancers, a high constitutive activation of transcription factor NF-kappaB has been implicated in tumor progression and apoptosis resistance, making NF-kappaB an attractive target for cancer therapy. Here, we describe the specific inhibition of NF-kappaB by the intracellular delivery of IkappaBalpha through VP22-mediated protein transduction. The Herpes virus protein VP22 has attracted great attention in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to I-kappa B Proteins
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to NF-kappa B

Share to NF-KappaB Inhibitor alpha

Share to Recombinant Fusion Proteins

Share to Transduction, Genetic

Share to Viral Proteins

Source

Identifiers

PMID: 12917639
DOI: 10.1038/sj.onc.1206544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific inhibition of transcription factor NF-kappaB through intracellular protein delivery of I kappaBalpha by the Herpes virus protein VP22.PMID 12917639Read ↗

Herpes simplex virus 1 VP22 regulates translocation of multiple viral and cellular proteins and promotes neurovirulence.Semantic proximity Read ↗

Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22Semantic proximity Read ↗

Identification of sequences in herpes simplex virus type 1 ICP22 that influence RNA polymerase II modification and viral late gene expression.Semantic proximity Read ↗

Nuclear and mitochondrial localization signals overlap within bovine herpesvirus 1 tegument protein VP22.Semantic proximity Read ↗

Phosphorylation of the herpes simplex virus tegument protein VP22 has no effect on incorporation of VP22 into the virus but is involved in optimal expression and virion packaging of ICP0.Semantic proximity Read ↗

Intercellular Trafficking of Adenovirus-Delivered HSV VP22 from the Retinal Pigment Epithelium to the Photoreceptors—Implications for Gene TherapySemantic proximity Read ↗

Particle assembly incorporating a VP22-BH3 fusion protein, facilitating intracellular delivery, regulated release, and apoptosis.Semantic proximity Read ↗

Direct evidence for the absence of intercellular trafficking of VP22 fused to GFP or to the herpes simplex virus thymidine kinase.Semantic proximity Read ↗

Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase.Semantic proximity Read ↗

Adenovirus-mediated overexpression of novel mutated IkappaBalpha inhibits nuclear factor kappaB activation in endothelial cells.Semantic proximity Read ↗

Characterization of NFkappaB activation by detection of green fluorescent protein-tagged IkappaB degradation in living cells.Semantic proximity Read ↗

Inhibition of NF-kappa B activity by a membrane-transducing mutant of I kappa B alpha.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.