Article
Inhibition of NF-kappa B activity by a membrane-transducing mutant of I kappa B alpha.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2002
Kabouridis Panagiotis S, Hasan Maemunah, Newson Justine, Gilroy Derek W, Lawrence Toby
Abstract excerpt
The transcription factor NF-kappaB is regulated by the IkappaB family of proteins. The nonphosphorylatable, nondegradable superrepressor IkappaBalpha (srIkappaBalpha) mutant is a potent inhibitor of NF-kappaB activity when expressed in cells. We generated a form of srIkappaBalpha in which its N terminus is fused to the protein transduction domain of HIV TAT (TAT-srIkappaBalpha). Purified TAT-srIkappaBalpha...
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