Gain-of-function mutations indicate that Escherichia coli Kch forms a functional K+ conduit in vivo.

Abstract excerpt

Although Kch of Escherichia coli is thought to be a K(+) channel by sequence homology, there is little evidence that it actually conducts K(+) ions in vitro or in vivo. We isolated gain-of-function (GOF) Kch mutations that render bacteria specifically sensitive to K(+) ions. Millimolar added K(+)...

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