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Article

Telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancer

11 Aug 2003

Abstract excerpt

BACKGROUND: and aims: Chromosomal instability is one of the most consistent markers of sporadic colorectal cancer in humans. There is growing evidence that telomere shortening is one of the mechanisms leading to chromosomal instability and cancer initiation. METHODS: To test this hypothesis, the telomere length of colorectal epithelial cells and cells from connective tissue was determined at the adenoma-carcinoma...

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PMID: 12912862
DOI: 10.1136/gut.52.9.1304

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