Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Linkage analysis of factor VIII and von Willebrand factor loci as quantitative trait loci.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2003

De Visser M C H, Sandkuijl L A, Lensen R P M, Vos H L, Rosendaal F R, Bertina R M

Abstract excerpt

Elevated factor (F)VIII levels contribute to venous thrombotic risk. FVIII levels are determined to a large extent by levels of von Willebrand factor (VWF), its carrier protein which protects FVIII against proteolysis. VWF levels are largely dependent on ABO blood group. Subjects with blood group non-O have higher VWF and FVIII levels than individuals with blood group O. Apart from ABO blood group no genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ABO Blood-Group System
Share to Factor V

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Factor VIII

Share to Family Health

Share to Likelihood Functions

Share to Thrombophilia

Share to von Willebrand Factor

Source

Identifiers

PMID: 12911592
DOI: 10.1046/j.1538-7836.2003.00314.x

Genes

VWF
ABO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Linkage analysis of factor VIII and von Willebrand factor loci as quantitative trait loci.PMID 12911592Read ↗

Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.Semantic proximity Read ↗

Genome-wide linkage analysis of von Willebrand factor plasma levels: results from the GAIT projectSemantic proximity Read ↗

Genetic linkage and association analysis in type 1 von Willebrand disease: results from the Canadian type 1 VWD study.Semantic proximity Read ↗

Genetic and blood coagulation characterization of "Swedish" families with von Willebrand's disease types I and III: new aspects of heredity.Semantic proximity Read ↗

Linkage of combined factors V and VIII deficiency to chromosome 18q by homozygosity mapping.Semantic proximity Read ↗

Functional effects of the ABO locus polymorphism on plasma levels of von Willebrand factor, factor VIII, and activated partial thromboplastin time.Semantic proximity Read ↗

The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism.Semantic proximity Read ↗

Significant linkage and non-linkage of type 1 von Willebrand disease to the von Willebrand factor gene.Semantic proximity Read ↗

Familial Clustering of Factor VIII and von Willebrand Factor LevelsSemantic proximity Read ↗

Heritability of elevated factor VIII antigen levels in factor V Leiden families with thrombophilia.Semantic proximity Read ↗

Location on the human genetic linkage map of 26 genes involved in blood coagulation.Semantic proximity Read ↗

Combined segregation-linkage analysis of plasma thrombin activatable fibrinolysis inhibitor (TAFI) antigen levels with TAFI gene polymorphisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.