Article
[Functional analysis of the single nucleotide polymorphisms in the PRKCZ gene].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae - 1 Oct 2002
Sun Hong-xia, Du Wei-nan, Li Yun-feng, Zuo Jin, Wu Guo-dong, Shen Yan, Qiang Bo-qin, Yao Zhi-jian, Hang Jian-mei, Luo Hui-yuan, Wang Heng, Huang Wei, Chen Zhu, Fang Fu-de
Abstract excerpt
OBJECTIVE: To study the function of 5 single nucleotide polymorphisms (SNPs) of the PRKCZ gene, a susceptibility gene for type 2 diabetes in Han population of North China, in the pathogenesis of the disease. METHODS: Bioinformatic methods and reporter gene activity determination were used to analyze the function of the 5 SNPs. RESULTS: The reporter gene activities of different alleles of 2 SNPs, rs427811 and...
Topics
- Alleles
- Asian People
- Diabetes Mellitus, Type 2
- Ethnicity
- Genetic Predisposition to Disease
- Humans
- Polymorphism, Single Nucleotide
- Protein Kinase C
- Protein Kinase C-delta