Article
Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a case-control study of a Chinese Han population.
Diabetes/metabolism research and reviews - 1 Sept 2008
Qin Lei, Zhou Ling, Wu Xueji, Cheng Jinluo, Wang Jingsong, Du Yunfeng, Hu Jihong, Shen Moyu, Zhou Jinyi
Abstract excerpt
BACKGROUND: Previous investigations of the protein kinase C zeta (PRKCZ) gene, a susceptibility factor for type 2 diabetes mellitus (T2DM), have focussed on its single nucleotide polymorphisms (SNPs). In a departure from these earlier studies, we tested six tagging markers of PRKCZ based on the Hapmap database to evaluate their association with T2DM. METHODS: PCR-RFLP was performed to test the genotypes in type 2...
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