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Article

Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both topoisomerase II isoforms.

BMC cancer - 18 Nov 2014

Deng Shiwei, Yan Tiandong, Jendrny Cathleen, Nemecek Andrea, Vincetic Mladen, Gödtel-Armbrust Ute, Wojnowski Leszek

Abstract excerpt

BACKGROUND: The bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced heart failure, but its clinical use is limited by uncertain cardioprotective mechanism and by concerns of interference with cancer response to anthracyclines and of long-term safety. METHODS: We investigated the effects of DRZ on the stability of topoisomerases IIα (TOP2A) and IIβ (TOP2B) and on the DNA damage generated by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25406834
DOI: 10.1186/1471-2407-14-842
PMCID: PMC4242484

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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