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Article

Effect of the anti-neoplastic drug doxorubicin on XPD-mutated DNA repair-deficient human cells.

DNA repair - 2 Jan 2010

Saffi Jenifer, Agnoletto Mateus H, Guecheva Temenouga N, Batista Luís F Z, Carvalho Helotonio, Henriques João A P, Stary Anne, Menck Carlos F M, Sarasin Alain

Abstract excerpt

Doxorubicin (DOX), a member of the anthracycline group, is a widely used drug in cancer therapy. The mechanisms of DOX action include topoisomerase II-poisoning, free radical release, DNA adducts and interstrand cross-link (ICL) formation. Nucleotide excision repair (NER) is involved in the remov...

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Source

Identifiers

PMID: 19926538
DOI: 10.1016/j.dnarep.2009.10.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19926538-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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