Article
Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos.
Molecular and cellular biology - 1 May 1995
Du S J, Purcell S M, Christian J L, McGrew L L, Moon R T
Abstract excerpt
Wnts are secreted signaling factors which influence cell fate and cell behavior in developing embryos. Overexpression in Xenopus laevis embryos of a Xenopus Wnt, Xwnt-8, leads to a duplication of the embryonic axis. In embryos ventralized by UV irradiation, Xwnt-8 restores expression of the putative transcription factor goosecoid, and rescues normal axis formation. In contrast, overexpression of Xwnt-5A in normal...
Topics
- Animals
- Base Sequence
- DNA Primers
- Embryo, Nonmammalian
- Female
- Gene Expression
- Molecular Sequence Data
- Phenotype
- Proto-Oncogene Proteins
- RNA Caps
- Recombinant Fusion Proteins