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Article

Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.

Nature structural biology - 1 Sept 2003

Fitzgerald Catherine E, Patel Sangita B, Becker Joseph W, Cameron Patricia M, Zaller Dennis, Pikounis Vasilis Bill, O'Keefe Stephen J, Scapin Giovanna

Abstract excerpt

The quinazolinone and pyridol-pyrimidine classes of p38 MAP kinase inhibitors have a previously unseen degree of specificity for p38 over other MAP kinases. Comparison of the crystal structures of p38 bound to four different compounds shows that binding of the more specific molecules is characterized by a peptide flip between Met109 and Gly110. Gly110 is a residue specific to the alpha, beta and gamma isoforms of...

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PMID: 12897767
DOI: 10.1038/nsb949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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