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Article

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase.

Chemistry & biology - 1 Jun 1997

Wilson K P, McCaffrey P G, Hsiao K, Pazhanisamy S, Galullo V, Bemis G W, Fitzgibbon M J, Caron P R, Murcko M A, Su M S

Abstract excerpt

BACKGROUND: The p38 mitogen-activated protein (MAP) kinase regulates signal transduction in response to environmental stress. Pyridinylimidazole compounds are specific inhibitors of p38 MAP kinase that block the production of the cytokines interleukin-1beta and tumor necrosis factor alpha, and they are effective in animal models of arthritis, bone resorption and endotoxin shock. These compounds have been useful...

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PMID: 9224565
DOI: 10.1016/s1074-5521(97)90194-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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