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Article

Association of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors.

Fertility and sterility - 1 Jul 2010

Su H Irene, Sammel Mary D, Velders Luke, Horn Michelle, Stankiewicz Corrie, Matro Jennifer, Gracia Clarisa R, Green Jamie, DeMichele Angela

Abstract excerpt

OBJECTIVE: To determine if genetic variation in chemotherapy metabolism are associated with risk of ovarian failure in breast cancer patients after adjuvant chemotherapy. DESIGN: Prospective cohort study. SETTING: Comprehensive cancer center. PATIENT(S): Early-stage breast cancer patients who were premenopausal at cancer diagnosis and treatment. INTERVENTION(S): None. MAIN OUTCOMES MEASURE(S):...

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Topics

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Share to Antineoplastic Agents, Alkylating
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2B6

Share to Cytochrome P-450 CYP3A

Share to Enzymes

Share to Glutathione S-Transferase pi

Share to Oxidoreductases, N-Demethylating

Share to Primary Ovarian Insufficiency

Source

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Identifiers

PMID: 19376514
DOI: 10.1016/j.fertnstert.2009.03.034
PMCID: PMC2891284

Genes

GSTA1
GSTM1
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors.PMID 19376514Read ↗

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Relationship of drug metabolizing enzyme genotype to plasma levels as well as myelotoxicity of cyclophosphamide in breast cancer patients.Semantic proximity Read ↗

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