Article
Toward a molecular neuropsychiatry of neurodegenerative diseases.
Annals of neurology - 1 Aug 2003
Cummings Jeffrey L
Abstract excerpt
Quantitative neuropsychiatry has provided increasingly precise descriptions of behavioral phenotypes associated with neurodegenerative disorders. Degenerative diseases of the brain are disturbances of protein metabolism, with failure of protein degredation by the ubiquitin-proteosome system, production of neurotoxic peptide oligomers, and accumulation of intracellular protein deposits. Abnormalities of amyloid...
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