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Article

Relevance of Akt phosphorylation in cell transformation induced by Jaagsiekte sheep retrovirus.

Virology - 20 Jul 2003

Zavala Guillermo, Pretto Carla, Chow Yen-Hung J, Jones LeeAnn, Alberti Alberto, Grego Elena, De las Heras Marcelo, Palmarini Massimo

Abstract excerpt

Expression of the JSRV envelope (Env) is sufficient to transform immortalized rodent fibroblasts. A putative docking site for the PI3-K kinase (Y(590)-X-X-M(593)) in the cytoplasmic tail of the transmembrane domain of the JSRV Env is a major determinant of viral-induced cell transformation. Akt is constitutively phosphorylated in rodent fibroblasts transformed by the JSRV Env. However, recent data suggest that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12890624
DOI: 10.1016/s0042-6822(03)00205-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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