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Article

Retrovirus-Induced Ovine Pulmonary Adenocarcinoma, an Animal Model for Lung Cancer

7 Nov 2001

Abstract excerpt

Studies on the molecular mechanisms of transformation of retrovirus-induced neoplasms in domestic and laboratory animal species have provided insights into the genetic basis of cancer. Ovine pulmonary adenocarcinoma (OPA) is a retrovirus-induced spontaneous lung tumor of sheep that has striking analogies to some forms of human adenocarcinoma. The etiologic agent of OPA, jaagsiekte sheep retrovirus (JSRV), is...

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PMID: 11698564
DOI: 10.1093/jnci/93.21.1603

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