Article
Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function.
Development (Cambridge, England) - 1 Jun 2000
Brickman J M, Jones C M, Clements M, Smith J C, Beddington R S
Abstract excerpt
One of the earliest markers of anterior asymmetry in vertebrate embryos is the transcription factor Hex. We find that Hex is a transcriptional repressor that can be converted to an activator by fusing full length Hex to two copies of the minimal transcriptional activation domain of VP16 together with the flexible hinge region of the (lambda) repressor (Hex-(lambda)VP2). Retention of the entire Hex open reading...
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