Article
Rad52 gene mutations in breast/ovarian cancer families and sporadic ovarian carcinoma patients.
Oncology reports - 1 Jan 2000
Tong Dan, Volm Tanja, Eberhardt Elke, Krainer Michael, Leodolter Sepp, Kreienberg Rolf, Zeillinger Robert
Abstract excerpt
Rad52 encodes a protein which is required for recombinational repair of double-strand breaks. It is also associated with breast cancer predisposition genes BRCA1 and BRCA2. Mutations in the genes Rad51 or Rad52 result in severe defects in genetic recombination and the repair of double-strand DNA breaks. In order to examine if Rad52 mutations might be involved in sporadic ovarian cancer, we analyzed two stop...
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