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Article

An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003

Grisolano Jay L, O'Neal Julie, Cain Jennifer, Tomasson Michael H

Abstract excerpt

The t(8;21)(q22;q22) translocation, occurring in 40% of patients with acute myeloid leukemia (AML) of the FAB-M2 subtype (AML with maturation), results in expression of the RUNX1-CBF2T1 [AML1-ETO (AE)] fusion oncogene. AML/ETO may contribute to leukemogenesis by interacting with nuclear corepressor complexes that include histone deacetylases, which mediate the repression of target genes. However, expression of AE...

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Source

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Identifiers

PMID: 12881486
DOI: 10.1073/pnas.1531730100
PMCID: PMC170948

Genes

PDGFRB
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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