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Article

VEGF-A and alphaVbeta3 integrin synergistically rescue angiogenesis via N-Ras and PI3-K signaling in human microvascular endothelial cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2003

Liu Zhao-Jun, Snyder Ruthanne, Soma Akinobu, Shirakawa Takashi, Ziober Barry L, Fairman Ronald M, Herlyn Meenhard, Velazquez Omaida C

Abstract excerpt

We recently showed that normal fibroblasts mediate capillary-like differentiation of human microvascular endothelial cells (HMVEC) in a 3-D angiogenesis model. Here, we show that a collaborative effect of VEGF-A and alphaVbeta3 integrin is critical in fibroblast-mediated angiogenesis because enha...

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Source

Identifiers

PMID: 14519669
DOI: 10.1096/fj.02-1171fje

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14519669-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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