Dual suppression of hemangiogenesis and lymphangiogenesis by splice‐shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR)

Abstract excerpt

The KDR gene, which participates in angiogenesis and lymphangiogenesis, produces two functionally distinct protein products, membrane‐bound KDR (mbKDR) and its isoform, soluble KDR (sKDR). Since sKDR does not have a tyrosine kinase domain and does not dimerize, it is principally an antagonist of lymphangiogenesis by sequestering VEGF‐C. Alternative polyadenylation of exon 30 or intron 13 leads to the production...

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