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Article

Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser⁷²⁷ on STAT3 in prostate cancer cells.

American journal of physiology. Endocrinology and metabolism - 15 Oct 2013

Hsu Fu-Ning, Chen Mei-Chih, Lin Kuan-Chia, Peng Yu-Ting, Li Pei-Chi, Lin Eugene, Chiang Ming-Ching, Hsieh Jer-Tsong, Lin Ho

Abstract excerpt

Cyclin-dependent kinase 5 (Cdk5) is known to regulate prostate cancer metastasis. Our previous results indicated that Cdk5 activates androgen receptor (AR) and supports prostate cancer growth. We also found that STAT3 is a target of Cdk5 in promoting thyroid cancer cell growth, whereas STAT3 may play a role as a regulator to AR activation under cytokine control. In this study, we investigated the regulation of...

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PMID: 23941877
DOI: 10.1152/ajpendo.00615.2012

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STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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