Article
Detection of cystic fibrosis mutations by peptide mass signature genotyping.
Clinical chemistry - 1 Aug 2003
Malehorn David E, Telmer Cheryl A, McEwen Sherri B, An Jiyan, Kinsey Ashley D, Retchless Adam C, Mason Christopher, Vieta William M, Jarvik Jonathan W
Abstract excerpt
BACKGROUND: The diversity of genetic mutations and polymorphisms calls for the development of practical detection methods capable of assessing more than one patient/one nucleotide position per analysis. METHODS: We developed a new method, based on peptide mass signature genotyping (PMSG), for the detection of DNA mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Exons of the gene...
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