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Article

Long-distance conformational changes in a protein engineered by modulated sequence duplication.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003

Sagermann Martin, Gay Leslie, Matthews Brian W

Abstract excerpt

There are few, if any, known instances in which a biological signal is transmitted via a large conformational change through the body of a protein. We describe here a mutant of T4 lysozyme that was engineered to permit structural change at a distance. The design uses a tandem sequence repeat that makes it possible to transmit large-scale structural changes from one end of an alpha-helix to the other over a...

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Identifiers

PMID: 12869697
DOI: 10.1073/pnas.1633549100
PMCID: PMC170894

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