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Article

Hepatitis B virus downregulates the human interferon-inducible MxA promoter through direct interaction of precore/core proteins

16 Jul 2003

Abstract excerpt

The human MxA protein is an interferon (IFN)-inducible GTPase with proven antiviral activity against diverse viruses. IFN responsiveness is impaired in chronic hepatitis B virus (HBV) infection. Accordingly, initial experiments showed that, in contrast to parental HepG2 cells, when HepG2-derived 2.2.15 liver cells carrying the HBV genome were treated with IFN, they could not synthesize the MxA protein....

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PMID: 12867637
DOI: 10.1099/vir.0.18966-0

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