Article
Recovery of adhesion to chondroitin-4-sulphate in Plasmodium falciparum varCSA disruption mutants by antigenically similar PfEMP1 variants.
Molecular microbiology - 1 Aug 2003
Andrews Katherine T, Pirrit Lindsay A, Przyborski Jude M, Sanchez Cecilia P, Sterkers Yvon, Ricken Sigrid, Wickert Hannes, Lépolard Catherine, Avril Marion, Scherf Artur, Gysin Jürg, Lanzer Michael
Abstract excerpt
Protection against maternal malaria has been associated with the acquisition of a specific antibody response that prevents adhesion of Plasmodium falciparum-infected erythrocytes to the glycosaminoglycan chondroitin-4-sulphate (CSA), which is present in the placental intervillous space. These antibodies are directed against variant forms of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) that mediate...
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