Article
Quantitative assessment of contaminating tumor cells in autologous peripheral blood stem cells of B-cell non-Hodgkin lymphomas using immunoglobulin heavy chain gene allele-specific oligonucleotide real-time quantitative-polymerase chain reaction.
Leukemia research - 1 Oct 2003
Yashima Akiko, Maesawa Chihaya, Uchiyama Michihiro, Tarusawa Mitsu, Satoh Takashi, Satoh Mamiko, Enomoto Sanae, Sugawara Ken, Numaoka Hideharu, Murai Kazunori, Utsugisawa Taiju, Ishida Yoji, Masuda Tomoyuki
Abstract excerpt
A real-time quantitative-polymerase chain reaction (RQ-PCR) targeting the immunoglobulin heavy chain (IgH) gene has been used for the quantification of minimal residual disease (MRD) in B-cell hematological malignancies. In non-Hodgkin lymphoma (NHL), experimental costs are increased, as a large number of primer-probe sets are required because of diversity, due to somatic and ongoing mutations of the IgH gene. We...
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