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Article

Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2003

Kamai Takao, Tsujii Toshihiko, Arai Kyoko, Takagi Kentaro, Asami Hidekazu, Ito Yuji, Oshima Hiroyuki

Abstract excerpt

PURPOSE: The small GTP-binding protein Rho and its best-characterized downstream effector Rho-associated serine-threonine protein kinase, ROCK, participate in actin cytoskeleton organization, and are linked to pathogenesis and progression of several human tumors. We investigated the roles of Rho...

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Source

Identifiers

PMID: 12855641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12855641-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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