Article
Region and amino acid residues required for Rad51C binding in the human Xrcc3 protein.
Nucleic acids research - 15 Jul 2003
Kurumizaka Hitoshi, Enomoto Rima, Nakada Maki, Eda Keiko, Yokoyama Shigeyuki, Shibata Takehiko
Abstract excerpt
The Xrcc3 protein, which is required for the homologous recombinational repair of damaged DNA, forms a complex with the Rad51C protein in human cells. Mutations in either the Xrcc3 or Rad51C gene cause extreme sensitivity to DNA-damaging agents and generate the genomic instability frequently found in tumors. In the present study, we found that the Xrcc3 segment containing amino acid residues 63-346,...
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