Article
Plasmodium falciparum CS protein--prime malaria vaccine candidate: definition of the human CTL domain and analysis of its variation.
Memorias do Instituto Oswaldo Cruz - 1 Jan 1992
Doolan D L, Good M F
Abstract excerpt
Studies in mice have shown that immunity to malaria sporozoites is mediated primarily by cytotoxic T lymphocytes (CTL) specific for epitopes within the circumsporozoite (CS) protein. Humans, however, had never been shown to generate CTL against any malaria or other parasite protein. The design of...
Topics
- Animals
- Antigens, Protozoan
- Epitopes
- Genetic Variation
- Humans
- Immunity, Cellular
- Malaria Vaccines
- Mice
- Papua New Guinea
- Peptide Fragments
- Plasmodium falciparum
- Polymorphism, Genetic
- Protozoan Proteins
- Sequence Homology, Amino Acid
- T-Lymphocytes, Cytotoxic