Identification of functional regulatory regions of the connexin32 gene promoter.

doi:10.1016/s0167-4781(03)00111-8

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Article

Identification of functional regulatory regions of the connexin32 gene promoter.

Biochimica et biophysica acta - 9 Jul 2003

Field Joanne M L, Tate Laura A, Chipman J Kevin, Minchin Stephen D

Abstract excerpt

Connexin32 (Cx32) is the predominant gap junction protein expressed in adult rat hepatocytes. This study investigated transcriptional regulation of the rat Cx32 gene in MH(1)C(1) rat hepatoma cells using transient expression assays in conjunction with promoter mutagenesis and 5' nested deletion analysis. Site-directed mutagenesis of the -736 and -187 hepatocyte nuclear factor-1 (HNF-1) sites, the -196 and -116...

Topics

Animals
Binding Sites
Connexins
DNA-Binding Proteins
Gene Deletion
Gene Expression Regulation
Hepatocyte Nuclear Factor 1
Hepatocyte Nuclear Factor 1-alpha
Hepatocyte Nuclear Factor 1-beta
Hepatocytes
Luciferases
Models, Genetic
Mutagenesis, Site-Directed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Plasmids

Promoter Regions, Genetic

Rats

Source

Open in PubMed

Identifiers

PMID: 12850269
DOI: 10.1016/s0167-4781(03)00111-8

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