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Article

Different consequences of EGR2 mutants on the transactivation of human Cx32 promoter.

Neurobiology of disease - 1 Feb 2003

Musso Marco, Balestra Piercesare, Taroni Franco, Bellone Emilia, Mandich Paola

Abstract excerpt

The early growth response 2 (EGR2) transcription factor plays a crucial role in peripheral nerve myelination. Mutations of this gene are associated with a wide variety of demyelinating neuropathies differing from each other in the severity of nerve injury. Although the expression of EGR2 mutants inhibits the transactivation of myelin gene promoters, the exact molecular mechanism by which these mutations cause the...

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Source

Identifiers

PMID: 12609493
DOI: 10.1016/s0969-9961(02)00018-9

Genes

EGR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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