Article
Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin.
Neuron - 3 Jul 2003
Lee Seung-Jae, Xu Hong, Kang Lin-Woo, Amzel L Mario, Montell Craig
Abstract excerpt
Photoreceptor cells adapt to bright or continuous light, although the molecular mechanisms underlying this phenomenon are incompletely understood. Here, we report a mechanism of light adaptation in Drosophila, which is regulated by phosphoinositides (PIs). We found that light-dependent translocation of arrestin was defective in mutants that disrupt PI metabolism or trafficking. Arrestin bound to PIP(3) in vitro,...
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