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Article

Genotyping of canine MHC gene DLA-88 by next-generation sequencing reveals high frequencies of new allele discovery and gene duplication.

HLA - 1 Nov 2022

Pyo Chul-Woo, Harkey Michael A, Torok-Storb Beverly, Storb Rainer, Wang Ruihan, Thomas Alexander S, Nelson Wyatt C, Geraghty Daniel E

Abstract excerpt

Dogs have served as one of the most reliable preclinical models for a variety of diseases and treatments, including stem/progenitor cell transplantation. At the genetic epicenter of dog transplantation models, polymorphic major histocompatibility complex (MHC) genes are most impactful on transplantation success. Among the canine class I and class II genes, DLA-88 has been best studied in transplantation matching...

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Identifiers

PMID: 36227705
DOI: 10.1111/tan.14752
PMCID: PMC9563979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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