Article
Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cell-derived macrophages.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jul 2003
Banerjea Akhil, Li Ming-Jie, Bauer Gerhard, Remling Leila, Lee Nan-Sook, Rossi John, Akkina Ramesh
Abstract excerpt
The phenomenon of RNA interference mediated by small interfering RNAs (siRNAs) is a potent gene-silencing mechanism. A number of recent studies demonstrated inhibition of HIV-1 replication in cultured cells using this approach. To make further progress and harness this technology for HIV-1 gene therapy in a stem cell setting, in vivo studies using primary hematopoietic cells are needed. Using an HIV-based...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.